SiQ

It's really tricky to give good advice that is also brief here. Because why a poker game's equilibrium does what it does usually relies on a massive amount of interdependent variables that humans just can't deal with.

But if I had to give a decent heuristic I'd say something like:
It's important to use more mixing when you can easily see that you will be punished (net dollars: so think of both frequency and avg pot size) for not doing so.

There's a video on the PioSolver YouTube page, I think the first one that I made, where I (probably not so eloquently) go over a decent example of this - where mixing occurs very frequently with quite a few groups of hands. And I talk about why that may be happening.

I got pretty bad headaches (and probably some migraines triggered) from the computer screen.
I used flux for a long time, and it did help.

I thought Gunnar's were not going to be helpful (based on some reviews I'd read), so I didn't waste my time on them. But then a poker buddy shipped me a pair, and the difference was huge for me. I really can't imagine working at the computer without them anymore.

They feel more subtle than flux, but are way more effective. They also have a slight magnification which is unexpectedly amazing to have (I might be getting old).

I can imagine not everyone will like them as much; but I now strongly recommend them. At least the pair I have (don't know the name, but they are frameless and huge lenses so they cover my entire field of vision).