16:05 In general I find it easier and I think I'am more balanced If I only lead here (2-2 flop, oop). I still have some checkraises against more agressive opponents.
The point is good and makes some sense that against a tighter range we can play differently. But it's very hard to implement and be exactly balanced. E.g.: 6h UTG opens, we defend BB, and 2-2... We have a fair amount 764, 864, etc in our range that will make a lot of gutshots. And our opponent doesnt, they always have 2xx. But we still have a fair amount of 235, 238, 237 in our range from the BB that will make strong 1c draw. Also with 764 we can get a 2, and have a strong 1c draw....I simply not like to split my ranges. Because with 764-2 we want to lead, with 764-3, 764-5, 764-8 we are not an EQ favourite to justify a lead.

42:30 I don't understand your question. I guess you mean that our opponent capped his range, because he checked 2-2-2 MP and took 1 card next street. That is (another) reason to raise here. In the other hands he showed some (slightly) bad agressive tendencies, and my blockers and his capped range makes this a perfect combo to raise.