Villain 1- Very aggressive, regular pro in all the local games.  PLO is his worst game and one of his biggest leaks is 3 and 4 betting with complete trash.  I've seen him 3 bet out of position to 400 with ak65 no suits.  Stack is approximately 2500.

Villain 2- Businessman.  Regular in the no limit games, recently started playing plo.  Rarely raises, have never seen him raise with low rundowns or mid rundowns.  Stack is approximately 6000.

Hero- Stack covers both

Hero BTN- straddle 20, SB fold, Villain 1(BB) calls, utg and utg+2 call, Villain 2 raises to 125 in HJ.  Hero 6543ss calls, villain 1 raises to 550, utg and utg+2 fold, villain 2 calls.  I was just wondering if I can profitably call this or is it just spew?