How bad is blocking the 2nd nut flush preflop?

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How bad is blocking the 2nd nut flush preflop?

Clearly AKQ2ss with A2s is better than AKQ2ss with AKs (because when we have AKs we remove 2nd nut flush draws and 2nd nut flushes from opponents' ranges when we make the nut draw or nuts), but are there any situations in which you play one hand pre but not the same exact hand with the only difference being you don't have AK of the same suit? And if so, when? It seems like there must be some situations where the EV discrepancy makes a difference, but I don't know what they are.

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