I am not a mid stakes player, but I don't think this is an appropriate question for low stakes.

When solvers provide a mixed solution for a hand preflop, the expected solutions are zero EV. The solver assumes perfect GTO play post flop. As humans we cannot play perfect post flop, nor is our opponent able to. To me this suggests that playing these hand in reality are not going to be zero EV. What would be the effect on our overall strategy if we removed all our hands preflop that play mixed strategies?