Firsty I think preflop is fold or 3bet with QTs unless you have a read on villain being a bad.
Either way I think he is never bluffing in this spot - especially not with the sizing he used after taking this line. We need to win this about 25% of the time with the odds we are getting, and I just don't see how that's going to happen.

Villain can have KK, JJ, 77, AdQd KTs JTs - all of which he could have checked on the flop and taken that line. His river play is a little bit odd and he's probably better off just value betting his entire value range in this spot because people just don't bluff/value bet nearly enough on rivers at 10nl, that said, I completely fail to see what bluffs he can show up with otr. I also don't think he is a very good reg given his nitty preflop stats and his weird post-flop line. So against a passive regfish this is just a sigh-fold imo.

KTs would make most sense but he can't have that. KK,JJ would probably bet flop always, AT wouldn't raise I think.

Given he minraised he might just Delaycbeted AQ, and rivered a straight. I really don't see him bluffing like this, and against his value range you most likely have a fold. It's pretty disgusting because it is a small raise but I would be very surprised if I was good against a 22/17 after calling this.

This and maybe T9s,T8s are the bottom of your betting range, and you need to defend 54% of that range so this can be folded anyways probably.

You're right he can't have KTs I missed that we block all those combos by the river. That said KT is in our range if QT is, we also have AQ in our range- at least the one combo with diamonds. I think that would make a better bluff-catcher in this spot right? Or is QTs literally the top part of our range here along with AT/KT?

Thanks for feedback. At time of hand i was hoping that hed just spazzed out on river with Ak, i didn't really think he had any boats in his range as i would expect him to bet flop with his sets with the pot 4 handed. Turn i think i am golden nearly always. River is strange because i was torn between value betting and checking back, Decided to value bet and obviously get put into a spot , i made a crying call because his line just looked so FOS. I coudn't put him on a value hand that raises pre then c/b/cr.
Preflop this could be a leak of mine calling hands that look pretty but CO was a fish also. But I tend to flat all suited broadway and pocket pairs IP if open raiser has a full stack so would appreciate some more feedback on my preflop flatting range.

Against a 3x open KTs and QTs are just dominated so often, and I think that they have too significant reverse implied odds against villain's opening range from early positions.
That said, it's probably pretty close, and if villain is bad/too loose or too passive then one can definitely make good arguments for flatting those.
I like flatting hands such as AQs maybe QJs or JTs but for me QT and KT usually don't make the cut for calling against regs. I might 3bet them along with A5-A2s and some 56s-76s combos but mostly my flatting range on the button against early positions is something like QQ-66, AKs-ATs, KQs-JTs, KJs and AK. I don't like calling hands such as AQo or AJo either as my DB shows significant loss when I do call those over a large sample, and a slight win if I 3bet them.
So yeah might be totally wrong but it's just how I've been running. Maybe I fail to hand read well enough to be able to include those in my flatting range preflop I'm not sure.