Could you clarify? By identifying spots do you mean specific hands like sometimes cking TP sometimes betting it?

I tend to mix up how I play hands in HU pots more often than in multi way pots, esp when playing with thinking players who I have developed history with. I do think game flow plays a big part and if you know how many tables V is playing you can use that against them.

I'm prob way off base though :) Looking forward to others thoughts

Interesting.. Can you give an example of a spot where two strata would have the same EV? Mathematically or hypothetically

It's really tricky to give good advice that is also brief here. Because why a poker game's equilibrium does what it does usually relies on a massive amount of interdependent variables that humans just can't deal with.

But if I had to give a decent heuristic I'd say something like:
It's important to use more mixing when you can easily see that you will be punished (net dollars: so think of both frequency and avg pot size) for not doing so.

There's a video on the PioSolver YouTube page, I think the first one that I made, where I (probably not so eloquently) go over a decent example of this - where mixing occurs very frequently with quite a few groups of hands. And I talk about why that may be happening.