I had mostly played online until recently where I've started to play a lot of live deep stacked cash games. There are spots that come up w/ 99-JJ where I normally flat w/ shallower stacks especially with fishier players behind, however, I was wondering what peoples thought were on 3betting hands like 1010 on the button to a loose middle position opener. These hands can be great to go in big multiway pots, but you can build a big pot in position, call a 4bet when deep, and potentially make some big hands in 3bet pots. Obviously there can be many flops that cause problems when called OOP.

So yeah, lets say you are 500bbs deep, good laggier MP opens, fold to you w/ 1010 on the btn, with a kind of fishy player in the SB who is not absolutely horrible. What is standard there? What about 3betting smaller pairs like 22-55? What if there are regs in the blinds? Or two fish in the blinds? Thanks.