Well, NL50 is typically going to have lower rake than NL10. Most NL10 games have at least a 10bb/100 rake structure. NL50 in general will have roughly 8bb/100 in rake. So, how do you deal with that if using software like this? Have to play tighter than suggested. That is a huge difference in the grand scheme of things. This is why some high rake sims appear super tight.

The reason winrate when you call 3bets is important because of this:

Example

You raise CO for 2bb and BTN 3bets to 6bb, when you fold, your winrate is -200bb/100. You put in 2bb and folded it, so you lose -2bb/hand or -200bb/100.

When you continue passively vs his 3b, now you have put in 6bb total. You lose 6bb when you put in chips and fold flop. I don't like taking that option. Now I am losing -600bb/100 or 6bb/100 when I call the 3b and fold the flop.

Now, you flop a draw. You check call 7bb. You see where I am going.

You have to compare future actions to your initial investment. If you simply folded, your ev is zero. You didn't fold, you put in 2bb since you raised.

A visual would be this:

If you had a big sample and you said when you RFI and face a 3b, your winrate is -70bb/100. That would be a very good winrate. I did not include the RFI sizing.

If you had a big sample and you said when you RFI and face a 3b, your winrate is -225bb/100. That would need a lot of work.

When you RFI and face a 3b, you have 3 options:

Lose 2bb when you fold

Put in 4bb more when you call (standard 3x IP sizing). This is the option that causes the most trouble. Now you have 6bb in the pot OOP, that is a tough spot for everyone.

You 4b, now he folds. You win the pot uncontested. Usually an 8bb +/- win when they fold to 4b.

You 4b and he calls. You are going to own this spot typically since your range as 4 bettor is much stronger than his range.

You 4b and he jams worse, massive win.

You 4b and he jams and you fold (obviously the worst result possible, but you are going to have very few 4b/folds in your range to begin with.

In short, calling too many 3 bets OOP is a HUGE leak but it is an easy one to fix.

16% sounds like a big number but it really isn't.

There are 1326 unique hands possible. We are raising 22% of them. This is like 290 combos +/- in that particular RFI range.

Of those combos, the calling defense portion is 16% of that range, which is roughly 46 combinations.

In your above photo, the red combos are calling. There are 5 pairs calling (5x6 = 30 combos). There are 8 combos of AQs/KQs. There are 12 combos of AKo calling. That is 30+8+12 = 50 combos.

I am assuming the Pink part of the graph is optional call/fold vs 3b?

You can use the same thinking for a ton of spots:

Think about when UTG raises first in and then 4 bets.

It is a common theme that 4b ranges in small stakes are low on "bluffs"

Say a player RFI UTG a 16% range. You 3 bet him on the button and then he 4 bets. In general, you will see pools 4 betting 9% to 15% of hands depending on position.

1326 * .16 = 212 combos in UTG RFI range.

You 3 bet him and he 4 bets.

He is going to be 4 betting between (212 * 9%) and (212 * 15%).

So he is 4 betting between 19 combos and 32 combos.

AKs/AKo is 16 combos already. AA/KK is 12 combos. AA/KK/AKs/AKo is 28 combos. This is a good way to visualize what a 4b range looks like.