GTO-play is a strategy that makes it impossible to loose money in the long run and is a theoretical construct.
So if 2 players play a perfect GTO-strategy none of them is going to loose money (no rake considered).
In real life people deviate from GTO all the time and so this called “equilibrium” rarely exists.
If one player deviates from GTO, playing a GTO-strategy yourself can (and will in reality) be a mistake that looses money in a lot of situations.
Best example is bluffcatching rivers. A solver might say that you would have to bluffcatch some spots with weaker hands.
But in reality people are not bluffing this spot and so your call becomes a loosing play.
If you implement a perfect GTO-strategy you will be a winning player at every stake.
But to really crush a stake, you should more concentrate on exploiting your opponents.

Learn GTO-play and learn when to deviate from it would be my advice.

Run a sim of chart vs chart (gto vs gto) and save it

Run a sim of chart vs pool (gto vs pool) and save it

Same parameters, same board, same bet sizes, etc

Open PIO or GTO+ with the 1st sim

Open a secondary window of PIO or GTO+ with the 2nd sim

Compare/contrast what they look like

Node lock for the high c bet OOP like the pool does

Mostly concentrate on how to play an unexploitable style vs your environment and that is where you will find your exploits.

Ex. If pool c bets 65% in a spot where PIO plays it as a 40% c bet, they are doing something drastically wrong and that is where you want to base your decisions.

In addition to the classic GTO vs explo argument:

No one plays remotely close to GTO. This is like asking "if I play chess like a computer will I crush?" Yes, of course, but not even the world champ plays that well.

no you need to study gto to find how how balanced ranges play and where the marginal ev spots where people are making mistake with hands very close to 0 ev and then exploit them.