How do you guys deal with the fact that we have to defend/3bet different ranges vs all the different raises preflop: pot, 3x, 2.5x, min and all the ones in between? Do you play a default range vs all sizes when multtabling? Or do make the effort to call/3bet wider vs each bet size as much as possible?

I find it hard to do so when multitabling to focus on people's opening size exactly and adjust by defending range accordingly so I am kinda auto piloting a range that is middleish. But I know I am losing ev by not calling enough vs very tiny raises and 3betting too wide against big raises. Its easy to plug in solvers and memorize what you are raising preflop, but pretty much impossible to memorize optimal defending ranges in every position vs multiple bet sizes. Wonder how us mere humans compensate for this.