Preflop GTO strategy is a bit complicated compared to river spots for example. There is not an easy answer for this and I'm not an expert, but you want to make sure that villain can't 4bet or 5bet profitably with some crappy hands. 50/50 frequency is a good starting point, but it's a bit more complicated than that.

Make some calculations and see what hands villain can 4bet or 5bet profitably, and if he can 4bet or 5bet with crappy hands like 76o, your strategy is probably too exploitable.

Thanks for your response.

Do you know why it's complicated? I would assume it would be a little like your river example, but the reason for my posting was noticing how high pokersnowie's bluff range, yes it looks a lot more like 50/50

Assume you are OTR and villain has a bluff catcher and your v-bets are always good against his hand and your bluffs are always bad- so there is no thin valuebets or merging going on, you want to choose a ratio which makes villain indifferent of calling or folding hence he will not exploit you by always calling because you bluff too much here or always folding because you have too few bluffs.

Now the perfect ratio depends on your bet size and the odds you lay. Say we choose to bet fullpot. Villain will get exactly 2/1 which means calling would be correct if he wins 33.33% or more when he calls. Now GTO wise your exact value to bluff range should refer to that meaning having 1 bluff combo for 2 valuecombos is the way to go (you bluff exactly these 33,33%), because villain cannot call everytime, yet fold everytime, so in the short run it just depends on whether his coincidentally right when calling- in the long run, he cannot win from your strategy.

Now here comes something which is irritating and counterintuitve at first sight:

Lets say we choose to overbet the river for 120% to 1000% pot with bluffs and value hands ---> go watch Isildur1 for this.

Now we lay villain pot odds from something like 35% to max 50% (50 is always the cap). Instinctivly we want to bluff less because we risk so much when we get called and v-bet more because we hope to extract more value. Given the idea that we have to focus on villains exploitative calling approach, we cannot keep the same value to bluff ratio of 2:1. In this case, villain will be good 33% of the time, but given the pot odds, he has to be right more often. So in his shoes, he could fold any given time vs the overbet and exploit us given our ratio is unbalanced concerning the chosen bet size. So in order to counter that, we should add more bluffs, so that villain cannot do x move all the time and profit.

Same goes for smaller bets, we bet 1/2 pot, villain needs 25% to call , we should have 25% bluffs here.

Thanks Dishar for the replies!