Blinds $2/4 6max. Hero ($400) CO ($880) BB ($400)

Raise in UTG+1 to $12 with KQs, CO flats (35/25, 3b 13% over 4k hands), BB flats. 

(pot $37) Flop As6c4h, BB checks, Hero bets $23, CO calls, BB folds

(pot $104) Turn Qd, Hero bets $75, CO calls. 

(pot $252) River 6d. Hero bets $290 and is all in...

My thoughts: He is an active player who I expect to 3b AK most of the time and AQ some of the time. He called fairly quickly on flop/turn, as he has been doing with marginalish holdings and has been folding river. No turned draws really came in other than some gut shots so I think this is a good hand to have as a barrel hand. I could check and bluff catch but think that given I block AK and with the Q turn, heavily block AQ, which is the hand he is more likely to flat with pre. Given my blockers, he very frequently has AJ, ATs, A9s, A8s, A7s, A5s (given his pre flop stats, and given his fast calls). The river is a great card, as I know he folds 6x on turns and now 66 is unlikely, A6s is less likely, and A4s is now just a bluff catcher. I think given how often I am going to have AQ, AK here and he rarely has it given my blockers, he just can't call, escp. when he might believe he's calling for a chop at best.