I don't want to make this too broad/general of a question (such as the thread title) so i'll provide examples and be a bit more specific lol ^^

What i'm trying to ask is how can we exploit a villain when... he takes either a weird line for value or a weird line as a bluff and how do we accurately distinguish between the two in a unclear spot where we aren't sure if villain is unbalanced to more value or bluffs?

Ex:
Such as when villain shouldn't have a wide value raising range or betting range given the way his ranges "should" be constructed in this spot and thus when you are against a type of villain who is capable of bluffing/has a bluffing range, but may pick bad spots/weird spots to bluff in... i'm sure most of you have come across a spot once in a while where villain bets or raises and you ask yourself what hands is he even betting/raising here?

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Example...Hand i played a while back:
2/5
(BB) Hero $700: Ah3c
(UTG) Villain I $755: Old man TAG, live tells: he was talking like he really understood the game, seems str8 forward so far but we'll see...
(MP) Villain II $550: Str8-forward TAG villain

Preflop: 6 limps to hero, Hero makes it 45 in BB, Villain I UTG calls 45, Villain II MP calls 45, everyone else folds,... 3-way

Flop, Pot = 150 (3 players)
9s9d6s
Hero x, VI x, VII x

Turn, Pot = 150 (3 players)
3h
Hero bets 60, VI raises to 160, VII folds, Hero?