Lot of MTT books/videos suggest to remove 22-44 from your early position opening range.

I would like to understand how are 22-44 any different from 55, 66:

1) Mostly you're going to flop two or three over cards with both 22-44 and 55, 66. You'll take a stab on flop and give up on turn.

2) Your chances of hitting a set are same with both. And you're hardly ever continuing on turn without a set.

3) If you get 3bet pre flop, your counter - strategy is same with both. You either call to hit a set if you're getting the right implied odds, or you fold. If you think villain is 3betting you light, you can 4bet shove with both (he's not going to call with A5 or A6).

I can understand why removing hands like AT and KJ from early position opening range is good - you can value own yourself to a better A or K if you hit top pair. But with small pairs, you know when you're good and when you're not.