I have been playing with exploitative adjustments and i was wondering how villain's strategy on later streets affects our strategy on earlier streets so i lock a turn strategy (GTO+) and check my optimal flop strategy only to find that it hardly changes, obviously (or not so much) because i can only lock the strategy for one specific turn card and to evaluate our flop strategy i must assume a turn strategy for all possible turns, which i cant do easily in GTO+. It conjured up 3 questions.

1) how accurate is turn/river node locking if our flop strategy when turn/river node locking doesnt account for villain's strategy on later streets. In other words, if villain is double barreling 100% that will obviously affect how we should play flops (and preflop) but when we're node locking turns we have assumed a flop strategy that disregards that effect.
2) do any other solvers reconcile this issue easily or is there another solution?
3) is the effect so minimal that i shouldnt even worry about it?