How to analyse whether a preflop call is profitable

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How to analyse whether a preflop call is profitable

Hey guys,
i would like some help in setting up sims. WIth all the shorter stacks in the games these days i need to get better at analysing hands vs them. So say i open the button and a 40bb stack 3bets me with range R and i have hand xxxx, i do not have enough preflop equity vs his get in range to get the hand in preflop, but what is the best way of analysing whether the hand can be profitably called preflop?

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