In one of Lefort's videos he brought up the idea of minimum defense frequency, which is how often you have to defend to deny your opponent a profitable bluff with atc. For example, a 2/3-pot bet has to work 40% of the time to be profitable, so we would have to defend at least 60% of our range.

Could there be some runouts so bad for our range/so good for our opponent's range that it's correct to defend less than minimum defense frequency? That is, our least bad option would be to give up with a large portion of our range?