Hero- effective stack with $825.
Villain - $900. One of the best regs around. TAG who rarely makes mistakes and also plays 5/10.
Villain2- $900. Tight/nitty and predictable. Always tries to slow play his big hands and misses value often.

Villain UTG opens to $20
Hero UTG+2 3bets to $65 with KK
Villain 2 next to act flats the $65.
UTG 4bets to $225
Hero?

Facing a 4bet here with a player behind me I felt like it's time to 5bet. If it were heads up, or very likely to go heads up, I would most certainly be flatting with all of my continuing range. Thoughts? Also, if 5bet is ideal, is it a jam or can we go something like $400 to keep the action open?

Thanks